Фармакологическое действие
Антибиотик группы аминогликозидов широкого спектра действия. Оказывает бактерицидное действие. Активно проникая через клеточную мембрану бактерий, необратимо связывается с 30S субъединицей бактериальных рибосом и, тем самым, угнетает синтез белка возбудителя.
Высокоактивен в отношении аэробных грамотрицательных бактерий: Escherichia coli, Shigella spp., Salmonella spp., Enterobacter spp., Klebsiella spp., Serratia spp., Proteus spp., Pseudomonas aeruginosa, Acinetobacter spp.
Активен также в отношении аэробных грамположительных кокков: Staphylococcus spp. (в т.ч. устойчивых к пенициллинам и другим антибиотикам), некоторых штаммов Streptococcus spp.
К гентамицину устойчивы Neisseria meningitidis, Treponema pallidum, некоторые штаммы Streptococcus spp., анаэробные бактерии.
Фармакокинетика
При наружном применении практически не всасывается. С обширных участков кожи, поврежденной (рана, ожог), покрытой грануляционной тканью, всасывание происходит быстро.
Показания активных веществ препарата
Гентамициновая мазь 0.1%
Инфекционно-воспалительные заболевания, вызванные чувствительными к гентамицину микроорганизмами: пиодермия (в т.ч. гангренозная), поверхностный фолликулит, фурункулез, сикоз, паронихии, инфицированный себорейный дерматит, инфицированное акне, вторичное бактериальное инфицирование при грибковых и вирусных инфекциях кожи, инфицированные кожные раны различной этиологии (ожоги, раны, трудно заживающие язвы, укусы насекомых), инфицированные варикозные язвы.
Режим дозирования
Способ применения и режим дозирования конкретного препарата зависят от его формы выпуска и других факторов. Оптимальный режим дозирования определяет врач. Следует строго соблюдать соответствие используемой лекарственной формы конкретного препарата показаниям к применению и режиму дозирования.
Наружно — 3-4 раза/сут.
Побочное действие
Аллергические реакции: местные — кожная сыпь, зуд, гиперемия кожи, чувство жжения; генерализованные — лихорадка, ангионевротический отек, эозинофилия.
При всасывании с обширных поверхностей кожи возможно развитие системных побочных реакций.
Прочие: лихорадка, развитие суперинфекции.
Противопоказания к применению
Повышенная чувствительность к гентамицину и другим антибиотикам группы аминогликозидов.
С осторожностью
При необходимости применения на обширных поверхностях кожи — неврит слухового нерва, миастения, паркинсонизм, ботулизм, почечная недостаточность (в т.ч. тяжелая почечная недостаточность с азотемией и уремией), беременность, лактация (грудное вскармливание), новорожденные (до 1 мес), в т.ч. недоношенные дети, пациенты пожилого возраста.
Применение при беременности и кормлении грудью
Гентамицин противопоказан при беременности. При необходимости применения в период лактации следует прекратить грудное вскармливание.
Применение при нарушениях функции почек
С осторожностью: почечная недостаточность (в т.ч. тяжелая почечная недостаточность с азотемией и уремией).
Применение у детей
С осторожностью применять у новорожденных, в т.ч. недоношенных детей.
Применение у пожилых пациентов
С осторожностью применять у пациентов пожилого возраста.
Особые указания
При нанесении на обширные поверхности кожи следует учитывать возможность резорбтивного действия.
Лекарственное взаимодействие
Одновременно или сразу после окончания курса лечения гентамицином не следует назначать препараты с ото- или нефротоксическим действием во избежание развития побочных эффектов.
от
86 руб.
Стоимость без учета доставки в РФ
Артикул:
8699525447630
Доступность:
Под заказ
Количество:
+
−
В один клик
Описание
GEMYSETIN %1 OFTALMIK POMAT (5 G) (баркод – 8699525447630) из Турции.
Есть вопрос? Задайте его любым удобным способом на странице контактов.
Характеристики
Где применяется:
Антиинфекционные препараты
Действующее вещество:
kloramfenikol
Производитель:
DEVA HOLDİNG A.Ş.
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Top 20 medicines with the same components:
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Name of the medicinal product
The information provided in Name of the medicinal product of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Name of the medicinal product in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
more…
Gemysetin
Qualitative and quantitative composition
The information provided in Qualitative and quantitative composition of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Qualitative and quantitative composition in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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Chloramphenicol
Therapeutic indications
The information provided in Therapeutic indications of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Therapeutic indications in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
more…
Gemysetin is a broad spectrum bacteriostatic antibiotic. It is active against a wide range of Gram-negative and Gram-positive organisms, including Salmonella typhi, Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae and Bacteroides fragilis. It has antirickettsial and antichlamydial activity. It is indicated for the topical treatment of superficial ocular infections caused by pathogens which are sensitive to it.
Gemysetin is indicated in adults and children.
Dosage (Posology) and method of administration
The information provided in Dosage (Posology) and method of administration of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Dosage (Posology) and method of administration in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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Posology
Adults (and the elderly) and children
One or two drops applied to each affected eye up to six times daily or more frequently if required. (Severe infections may require one to two drops every fifteen to twenty minutes initially, reducing the frequency of instillation gradually as the infection is controlled).
Paediatric population
Dosage adjustment may be necessary in newborn infants because of reduced systemic elimination due to immature metabolism and the risk of dose-related adverse effects. The maximum duration of treatment is 10-14 days.
Method of administration
For topical ocular use.
Contraindications
The information provided in Contraindications of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Contraindications in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
more…
—
— Myelosuprresssion during previous exposure to Gemysetin.
— Known personal or family history of blood dyscrasias including aplastic anaemia
Special warnings and precautions for use
The information provided in Special warnings and precautions for use of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Special warnings and precautions for use in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
more…
Gemysetin is absorbed systemically from the eye and toxicity has been reported following chronic exposure.
Bone marrow hypoplasia, including aplastic anaemia and death, has been reported following topical use of Gemysetin. Whilst the hazard is a rare one, it should be borne in mind when assessing the benefits expected from the use of the compound.
Where Gemysetin eye drops are used on a long term or intermittent basis, it may be advisable to perform a routine blood profile before therapy and at appropriate intervals thereafter to detect any haemopoietic abnormalities.
In severe infections topical use of Gemysetin should be supplemented with appropriate systemic treatment.
Prolonged use should be avoided as it may increase the likelihood of sensitisation and the emergence of resistant organisms.
If any new infection appears during the treatment, the antibiotic should be discontinued and appropriate measures taken. Gemysetin should be reserved for use only in infections for which it is specifically indicated.
Gemysetin Eye Drops does not provide adequate coverage against Pseudomonas aeruginosa and Serratia marcescens.
Do not use for more than 5 days without consulting a doctor.
Medical advice should be sought if there is no improvement in the condition after 2 days or if symptoms worsen at any time.
Patients should be referred to their doctor if any of the following apply:
— Disturbed vision
— Severe pain within the eye
— Photophobia
— Eye inflammation associated with a rash on the scalp or face
— The eye looks cloudy
— The pupil looks unusual
— Suspected foreign body in the eye
Patients should also be referred to their doctor if any of the following in his/her medical history apply:
— Previous conjunctivitis in the recent past
— Glaucoma
— Dry eye syndrome
— Eye surgery or laser treatment in the last 6 months
— Eye injury
— Current use of other eye drops or eye ointment
— Contact lens use
Soft contact lenses should not be worn during treatment with Gemysetin eye drops due to absorption of the preservative onto the lens which may cause damage to the lens. It is recommended that all types of contact lenses be avoided during ocular infections.
The packaging will convey the following information:
— If symptoms do not improve within 48 hours talk to your doctor
— Seek further immediate medical advice at any time if symptoms worsen
— Do not use if you are allergic to Gemysetin or any of the ingredients
Phenylmercuric nitrate is irritating to the skin. Topical application to eyes has been associated with mercurialentis and atypical band keratopathy.
Effects on ability to drive and use machines
The information provided in Effects on ability to drive and use machines of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Effects on ability to drive and use machines in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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The use of the eye drops may cause transient blurring of vision. Patients should not drive or operate hazardous machinery unless vision is clear.
Undesirable effects
The information provided in Undesirable effects of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Undesirable effects in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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Eye disorders:
Transient irritation, burning, stinging and sensitivity reactions such as itching and dermatitis.
Immune System Disorders:
Hypersensitivity reactions including angioedema, anaphylaxis, urticaria, fever, vesicular and maculopapular dermatitis.
Blood and lymphatic system disorders:
Bone marrow depression and rarely aplastic anaemia has been reported following topical use of Gemysetin. Whilst the hazard is a rare one, it should be borne in mind when assessing the benefits expected from the use of this compound.
Reporting of suspected adverse reactions:
Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via Yellow card scheme at www.mhra.gov.uk/yellowcard.
Overdose
The information provided in Overdose of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Overdose in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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Accidental ingestion of the drops is unlikely to cause systemic toxicity due to the low content of the antibiotic in the product. If irritation, pain, swelling, lacrimation or photophobia occur after undesired eye contact, the exposed eye(s) should be irrigated for at least 15 minutes. If symptoms persist after this, an ophthalmological examination should be considered.
Pharmacodynamic properties
The information provided in Pharmacodynamic properties of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Pharmacodynamic properties in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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Pharmacotherapeutic group: Antibiotics
ATC code: S01AA01
Gemysetin is a broad spectrum antibiotic with bacteriostatic activity and is effective against a wide range of gram-negative and gram-positive organisms including Haemophilus influenzae, Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus viridans, Moraxella species and Enterobacteriaceae, the main pathogens responsible for acute bacterial conjunctivitis. Gemysetin exerts its antibacterial effect by reversibly binding to bacterial ribosomes thereby inhibiting bacterial protein synthesis.
Pharmacokinetic properties
The information provided in Pharmacokinetic properties of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Pharmacokinetic properties in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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Evidence suggests that Gemysetin is absorbed systemically via topical ocular administration. Any Gemysetin that is absorbed will be widely distributed in the body tissues and fluids. It is found in cerebrospinal fluid, is secreted in saliva, with the highest concentrations occurring in the kidneys and liver.
Gemysetin also diffuses across the placenta into the foetal circulation and into breast milk.
Gemysetin is excreted chiefly in the urine as the glucuronide with small amounts being excreted via the bile and faeces. It has a reported half life of 1.5 to 5 hours which is increased in patients with liver impairment and neonates to between 24 and 28 hours in the latter.
Pharmacotherapeutic group
The information provided in Pharmacotherapeutic group of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Pharmacotherapeutic group in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
more…
Antibiotics
Preclinical safety data
The information provided in Preclinical safety data of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Preclinical safety data in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
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No additional data of relevance to the prescriber.
Incompatibilities
The information provided in Incompatibilities of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Incompatibilities in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
more…
None known
Special precautions for disposal and other handling
The information provided in Special precautions for disposal and other handling of Gemysetin
is based on data of another medicine with exactly the same composition as the Gemysetin.
. Be careful and be sure to specify the information on the section Special precautions for disposal and other handling in the instructions to the drug Gemysetin directly from the package or from the pharmacist at the pharmacy.
more…
No special requirements.
Gemysetin price
We have no data on the cost of the drug.
However, we will provide data for each active ingredient
The approximate cost of Chloramphenicol 250 mg per unit in online pharmacies is from 0.5$ to 0.61$, per package is from 51$ to 112$.
References:
- https://www.drugs.com/search.php?searchterm=gemysetin
- https://pubmed.ncbi.nlm.nih.gov/?term=gemysetin
Available in countries
Find in a country:
Описание препарата Фуцидин® (мазь для наружного применения, 2%) основано на официальной инструкции, утверждено компанией-производителем в 2014 году
Дата согласования: 26.08.2014
Особые отметки:
Содержание
- Фотографии упаковок
- Действующее вещество
- ATX
- Фармакологическая группа
- Нозологическая классификация (МКБ-10)
- Состав
- Описание лекарственной формы
- Фармакологическое действие
- Фармакодинамика
- Фармакокинетика
- Показания
- Противопоказания
- Способ применения и дозы
- Побочные действия
- Взаимодействие
- Передозировка
- Особые указания
- Форма выпуска
- Производитель
- Условия отпуска из аптек
- Условия хранения
- Срок годности
- Заказ в аптеках Москвы
Действующее вещество
ATX
Фармакологическая группа
Состав
| Крем для наружного применения | 1 г |
| активное вещество: | |
| фузидовой кислоты гемигидрат (в пересчете на кислоту безводную) | 20,4 мг |
| (эквивалентно 20 мг фузидовой кислоты безводной) | |
| вспомогательные вещества: цетиловый спирт — 111 мг; глицерол 85% — 111 мг; парафин жидкий (содержит около 10 ppm альфа-токоферола) — 111 мг; парафин мягкий белый (содержит около 10 ppm альфа-токоферола) — 56 мг; полисорбат 60 — 56 мг; хлористоводородная кислота — q.s. до рН 5; калия сорбат — 2,7 мг; бутилгидроксианизол — 0,04 мг; вода — около 531 мг |
| Мазь для наружного применения | 1 г |
| активное вещество: | |
| натрия фузидат | 20 мг |
| вспомогательные вещества: ланолин (содержит не более 200 ppm бутилгидрокситолуола) — 46 мг; цетиловый спирт — 4 мг; парафин жидкий (содержит около 10 ppm альфа-токоферола) — 140 мг; парафин мягкий белый (содержит около 10 ppm альфа-токоферола) — 790 мг |
Описание лекарственной формы
Крем: гомогенный, от белого до почти белого цвета.
Мазь: гомогенная полупрозрачная, от желтоватого до белого цвета.
Фармакологическое действие
Фармакологическое действие
—
антибактериальное местное.
Фармакодинамика
Бактериостатический антибиотик.
Фузидовая кислота относится к группе фузидинов, антимикробных соединений, механизм действия которых связан с нарушением синтеза белка в бактериальной клетке.
К фузидовой кислоте чувствительны грамположительные бактерии и грамотрицательные кокки, например Staphylococcus aureus, Staphylococcus epidermidis (включая метициллинрезистентные штаммы), Nocardia asteroides, Corynebacterium minutissimum, Streptococcus pyogenes, Pseudomonas spp., Clostridium spp., Neisseria meningitidis, Neisseria gonorrhoeae.
Неактивен в отношении Escherichia coli, Salmonella spp., Proteus spp. и других грамотрицательных бактерий, а также простейших и грибов.
Фармакокинетика
Проницаемость фузидовой кислоты через интактную кожу низкая. В системный кровоток не попадает.
Показания
Кожные инфекции, вызванные бактериями, чувствительными к фузидовой кислоте.
Противопоказания
Гиперчувствительность к компонентам препарата.
С осторожностью: беременность, период лактации.
Способ применения и дозы
Реклама: ООО «РЛС-Патент», ИНН 5044031277, erid=4CQwVszH9pUkpHxmQQo
Реклама: ООО «РЛС-Патент», ИНН 5044031277, erid=4CQwVszH9pUkpHxmQQo
Наружно.
Взрослые и дети с рождения до 18 лет. Наносят на пораженные участки кожи тонким слоем 3–4 раза в день.
При использовании марлевых повязок частота нанесения может быть уменьшена до 1–2 раз в день.
Продолжительность лечения зависит от формы и тяжести заболевания и в среднем составляет 7–14 дней.
Побочные действия
Ниже приводятся данные о неблагоприятных побочных реакциях, в зависимости от частоты из возникновения: очень часто — ≥1/10; часто — ≥1/100, <1/10; нечасто — ≥1/1000, <1/100; редко — ≥1/10000, <1/1000; очень редко — <1/10000.
Со стороны кожи и подкожных тканей: нечасто — сыпь (эритематозная, макулопапулезная, пустулезная), раздражение кожи, включая боль, чувство жжения, чувство покалывания на коже, зуд, сухость кожи, контактный дерматит; редко — крапивница, ангионевротический отек, экзема, периорбитальный отек, эритема.
Со стороны иммунной системы: редко — аллергические реакции.
Со стороны органа зрения: редко — раздражение конъюнктивы.
Если любые из указанных в инструкции побочных эффектов усугубляются, или пациент заметил любые другие побочные эффекты, не указанные в инструкции, следует сообщить об этом врачу.
Взаимодействие
Реклама: ООО «ВЕДАНТА», ИНН 7714886235, erid 4CQwVszH9pUkKJ7jUDd
Реклама: ООО «РЛС-Библиомед» ИНН 7714758963
Реклама: ООО «ВЕДАНТА», ИНН 7714886235, erid 4CQwVszH9pUkKJ7jUDd
Реклама: ООО «РЛС-Библиомед» ИНН 7714758963
Не выявлено.
Передозировка
Маловероятна.
Особые указания
Не следует наносить Фуцидин® на кожу в области глаз, поскольку фузидовая кислота, при попадании в глаза, вызывает раздражение конъюнктивы.
Фуцидин® крем содержит бутилгидроксианизол, цетиловый спирт и калия сорбат, которые могут послужить причиной появления местных аллергических кожных реакций (например контактный дерматит). Бутилгидроксианизол также может послужить причиной появления раздражения глаз и слизистых оболочек.
Фуцидин® мазь содержит ланолин и цетиловый спирт, которые могут послужить причиной появления местных аллергических кожных реакций (например контактный дерматит).
При использовании фузидовой кислоты может развиться бактериальная устойчивость. Как и у других антибиотиков, длительное или периодически повторяющееся использование может увеличить риск развития устойчивости к антибиотикам.
Влияние на способность управлять транспортными средствами и работать с механизмами. Влияние на способность управлять транспортными средствами и сложными механизмами не выявлено.
Форма выпуска
Крем для наружного применения, 2%. В тубе алюминиевой, лакированной изнутри, с навинчивающейся ПЭ-крышкой, 15 г. 1 туба в картонной пачке.
Мазь для наружного применения, 2%. В тубе алюминиевой, лакированной изнутри, с навинчивающейся ПЭ-крышкой, 15 г. 1 туба в картонной пачке.
Производитель
ЛЕО Лэбораторис Лимитед. 285 Кешел Роад, Дублин 12, Ирландия.
Владелец регистрационного удостоверения/выпускающий контроль качества: ЛЕО Фарма А/С. Индустрипаркен 55, ДК-2750 Баллеруп, Дания.
Организация, принимающая претензии потребителей: ООО «ЛЕО Фармасьютикал Продактс». 125315, Россия, Москва, Ленинградский пр-т, 72, корп. 2.
Тел.: (495) 789-11-60.
Электронная почта: info.ru.@leo-pharma.com
Условия отпуска из аптек
По рецепту.
Условия хранения
При температуре не выше 30 °C.
Хранить в недоступном для детей месте.
Срок годности
3 года.
После вскрытия тубы срок годности 3 мес.
Не применять по истечении срока годности, указанного на упаковке.
Представленная информация о ценах на препараты не является предложением о продаже или покупке товара.
Информация предназначена исключительно для сравнения цен в стационарных аптеках, осуществляющих деятельность в
соответствии со статьей 55 Федерального закона «Об обращении лекарственных средств» от 12.04.2010 № 61-ФЗ.
Gemysetin
Gemysetin inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae.
Gemysetin is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically. Gemysetin is effective against a wide variety of microorganisms, but due to serious side-effects (e.g., damage to the bone marrow, including aplastic anemia) in humans, it is usually reserved for the treatment of serious and life-threatening infections (e.g., typhoid fever). Gemysetin is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Gemysetin stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.
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Uses
Gemysetin is used for Ocular infections, Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H. influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple’s disease, Otitis externa
Gemysetin is also used to associated treatment for these conditions: Acne, Bacterial Conjunctivitis, Bacterial Conjunctivitis caused by susceptible bacteria, Bacterial Infections, Bacterial dacryocystitis, Bacterial diarrhoea, Conjunctivitis allergic, Corneal Inflammation, Eye swelling, Keratitis bacterial, Ocular Inflammation, Trachoma, Anterior eye segment inflammation, Bacterial blepharitis, Bacterial corneal ulcers, Non-purulent ophthalmic infections caused by susceptible bacteria, Superficial ocular infections, Skin disinfection
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How Gemysetin works
Gemysetin is lipid-soluble, allowing it to diffuse through the bacterial cell membrane. It then reversibly binds to the L16 protein of the 50S subunit of bacterial ribosomes, where transfer of amino acids to growing peptide chains is prevented (perhaps by suppression of peptidyl transferase activity), thus inhibiting peptide bond formation and subsequent protein synthesis.
Gemysetin
| Trade Name | Gemysetin |
| Availability | Prescription only |
| Generic | Chloramphenicol |
| Chloramphenicol Other Names | Chloramphénicol, Chloramphenicol, Chloramphenicolum, Chlornitromycin, Cloramfenicol, Cloranfenicol, Laevomycetinum, Levomicetina, Levomycetin |
| Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, triamcinolone |
| Type | |
| Formula | C11H12Cl2N2O5 |
| Weight | Average: 323.129 Monoisotopic: 322.012326918 |
| Protein binding |
Plasma protein binding is 50-60% in adults and 32% is premature neonates. |
| Groups | Approved, Vet approved |
| Therapeutic Class | Ear Anti-Infectives & Antiseptics, Eye Anti-Infectives & Antiseptics |
| Manufacturer | |
| Available Country | Turkey |
| Last Updated: | June 22, 2022 at 11:59 pm |
Structure
Table Of contents
- Gemysetin
- Uses
- Dosage
- Side Effect
- Precautions
- Interactions
- Uses during Pregnancy
- Uses during Breastfeeding
- Accute Overdose
- Food Interaction
- Half Life
- Volume of Distribution
- Clearance
- Interaction With other Medicine
- Contradiction
- Storage
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Dosage
Gemysetin dosage
For Eye: Adults, children and infants (all age groups): One or two drops 4 to 6 times a day should be placed in the infected eyes. If necessary the frequency of dose can be increased. Treatment should be continued for approximately 7 days but should not be continued for more than three weeks without re-evaluation by the prescribing physician.
For Ear: 2 to 3 drops into ear canal thrice or four times daily.
Otic/Aural: Otitis externa: Instill 2-3 drops of a 5% solution into the ear bid-tid.
Oral: Bacterial meningitis, Anaerobic bacterial infections, Anthrax, Brain abscess, Ehrlichiosis, Gas gangrene, Granuloma inguinale, Infections caused by H. influenzae, Listeriosis, Plague, Psittacosis, Q fever, Severe gastroenteritis, Severe melioidosis, Severe systemic infections with Camphylobacter fetus, Tularaemia, Whipple’s disease:
- Adult: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections due to moderately resistant organisms. Continue treatment after the patient’s temperature has normalised for a further 4 days in rickettsial disease and 8-10 days in typhoid fever.
- Child: Premature and full-term neonates: 25 mg/kg/day in 4 divided doses. Full-term infants >2 wk: 50 mg/kg/day in 4 divided doses. Children: 50 mg/kg/day in 4 divided doses increased to 100 mg/kg/day for meningitis or severe infections.
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Side Effects
Oral: GI symptoms; bleeding; peripheral and optic neuritis, visual impairment, blindness; encephalopathy, confusion, delirium, mental depression, headache. Haemolysis in patients with G6PD deficiency.
ophthalmic application: Hypersensitivity reactions including rashes, fever and angioedema.
Ear drops: Ototoxicity.
Toxicity
Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.
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Precaution
Impaired renal or hepatic function; premature and full-term neonates. Monitor plasma concentrations to avoid toxicity.
Interaction
Decreased effects of iron and vitamin B12 in anaemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives.
Food Interaction
- Take on an empty stomach.
Gemysetin Drug Interaction
Moderate: cyanocobalamin, cyanocobalamin
Unknown: aspirin, aspirin, epinephrine, epinephrine, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, glycerin, glycerin, acetaminophen, acetaminophen, valproic acid, valproic acid, pyridoxine, pyridoxine, cholecalciferol, cholecalciferol, phytonadione, phytonadione
Gemysetin Disease Interaction
Major: colitis, bone marrow suppression, renal/liver disease
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Elimination Route
Rapidly and completely absorbed from gastrointestinal tract following oral administration (bioavailability 80%). Well absorbed following intramuscular administration (bioavailability 70%). Intraocular and some systemic absorption also occurs after topical application to the eye.
Half Life
Half-life in adults with normal hepatic and renal function is 1.5 — 3.5 hours. In patients with impaired renal function half-life is 3 — 4 hours. In patients with severely impaired hepatic function half-life is 4.6 — 11.6 hours. Half-life in children 1 month to 16 years old is 3 — 6.5 hours, while half-life in infants 1 to 2 days old is 24 hours or longer and is highly variable, especially in low birth-weight infants.
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Pregnancy & Breastfeeding use
Pregnancy Category C. Either studies in animals have revealed adverse effects on the fetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the fetus.
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Contraindication
History of hypersensitivity or toxic reaction to the drug; pregnancy, lactation; porphyria; parenteral admin for minor infections or as prophylaxis; preexisting bone marrow depression or blood dyscrasias.
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Storage Condition
Cap/susp: Store at temp not exceeding 30°C.
Ophth/otic preparation: Store between 2-8°C. Do not freeze. Protect from light.
Innovators Monograph
You find simplified version here Gemysetin
FAQ
What is Gemysetin used for?
Gemysetin is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. It’s mainly used to treat eye infections (such as conjunctivitis) and sometimes ear infections.
How safe is Gemysetin?
Gemysetin is safe for most adults and children. For most eye infections, you’ll usually start to see an improvement within 2 days of using Gemysetin. For ear infections, you should begin to feel better after a few days.
How does Gemysetin work?
Gemysetin is a bacteriostatic by inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome.
What are the common side effects of Gemysetin?
Common side effects of Gemysetin are include:
- not enough red blood cells produced (aplastic anemia)
- bone marrow suppression
- diarrhea
- inflammation of the small intestine and the colon (enterocolitis)
- accumulation of chloramphenicol especially in newborns (gray syndrome)
- headache
- nausea
- nightmares
- inflammation of the optic nerve
- weakness and numbness in your hands and feet
- rash
- inflamed and sore mouth
- vomiting
Is Gemysetin safe during pregnancy?
There is a wealth of clinical data demon-strating that Gemysetin is safe to use in pregnancy if it is not circulating at the time of delivery, since the drug will cause gray syndrome in neonates. It does not seem to harm the fetus, however, which makes it safe to use during most of the pregnancy.
Is Gemysetin safe during breastfeeding?
If Gemysetin is considered the appropriate treatment it can be used as normal by breastfeeding mothers. Use of Gemysetin during breastfeeding is considered to be of concern by the American Academy of Pediatrics; according to some experts, this drug should be avoided.
Can I drink alcohol with Gemysetin?
Yes, you can drink alcohol with Gemysetin.
Can I drive after taking Gemysetin?
Gemysetin shouldn’t affect you being able to drive or cycle. However, if you experience stinging or burning immediately after applying the eye drops, do not drive or operate machinery immediately. Wait until your eyes are comfortable again and your vision is clear.
When should be taken of Gemysetin?
Your doctor may recommend using eye ointment at bedtime and eye drops during the day.If you’re using 1% Gemysetin eye ointment, apply it to the affected eye every 3 hours. Do this 3 to 4 times a day, or as your doctor advises.
Can I take Gemysetin on empty stomach?
Gemysetin is best taken with a full glass of water on an empty stomach (either 1 hour before or 2 hours after meals), unless otherwise directed by your doctor.
Who should not take Gemysetin?
If you have liver problems, decreased kidney function, a patient who is producing milk and breastfeeding, anemia due to depressed bone marrow you should not take Gemysetin.
What happen if I overdose on Gemysetin?
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
How long does Gemysetin take to work?
You’ll usually start to see an improvement within 2 days of using Gemysetin. For ear infections, you should begin to feel better after a few days. Your eyes may sting for a short time after using the eye drops or ointment.
What is the half-life of Gemysetin?
The apparent half-life of Gemysetin was extremely variable, ranging from 1.7 to 12.0 hours with a mean of 5.1 hours. Apparent half-lives were inversely correlated with age.
Can I take Gemysetin for a long time?
Prolonged use of Gemysetin eye drops should be avoided as it may increase the likelihood of sensitisation and emergence of resistant organisms. If any new infection appears during the treatment, the antibiotic should be discontinued and appropriate measures taken.
How long can I take Gemysetin?
Do not use them for more than 5 days, unless your doctor tells you to. This is because your eyes can become more sensitive or you could get another eye infection.
When should I stop taking Gemysetin?
Eye ointment use the ointment until the eye appears normal and for 2 days afterwards. Do not use it for more than a week, unless your doctor tells you to. Ear drops use the drops for up to a week. Avoid using the medicine for longer than this unless your doctor tells you to.
What happen If I missed dose of Gemysetin?
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
Can Gemysetin affect my fertility?
There’s no firm evidence to suggest that taking chloramphenicol will reduce fertility in either men or women.
Can Gemysetin affects my kidney?
Though Gemysetin was found to be hepatotoxic, there is no strong evidence to suggest that Gemysetin is nephrotoxic according to this study, There was no noticeable pathological changes observe from renal histopathology.