Candimax 200 инструкция по применению

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Each capsule contains 200 mg fluconazole.

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CAND0MAX is indicated for the treatment of conditions1n in a_a1:
«Inclusion in cryptocoxic meningitis and pier organs1n (such as accier and skin) infections1 ?cryptococcosis to the ground. A0DS li patients, organ transplant 1lm1_ or imm?Patients with pier causes of nosuppression or found normal can be treated. Fluconazole is cryptocoxic in patients with A0DS 11n n?ks?n? ?nleme i?can be used as a maintenance therapy.
«Including candidia, dyssemia candidiasis and bow1l1c1 (invasive) candida infections1n1n pier forms1 ?zere systemic candidiasis. These are peritoneum, endocardium, g?z, accier and urinary tract1 covers infections1n1. Habis is sick11, you look1m ?lying in its attributes, cytotoxic or imm?nosupressive therapy g?ren or candida infections1na predisposing dier fax?Patients with rler found can be treated.
«Mucosal candidiasis. These are 1n aras1nda orofarenjeal ?zofajeal, non-yay1l1c1 (non-invasive) bronchopulmonary infections, candid?ri and mucoc?tan and chronic oral atrophic candidiasis (a1z i?prostheses that hurt in) vard1r. Normal or ba1_1kl1k functions1 disruption_ patients can be treated.
«Fungal infections in patients with predisposing to fungal infections as a result of cytotoxic chemotherapy or radiotherapy due to Habis sick1k ?in nlen.
«0mm?n system in adequate patients, in deep endemic mycoses including coccidioidomycosis, paracoxidioidomycosis, sporotrichosis and histoplasmosis.

Instructions for proper use and dose/ application frequency
The daily dose of fluconazole should depend on the type and severity of the fungal infection. In types of infections that require treatment with recurrent doses, treatment should continue until clinical parameters or laboratory tests indicate that active fungal infection has passed. An insufficient duration of treatment causes recurrence of active infection. To prevent relapse; Treatment of AIDS li and cryptocoxic meningitis is required..
If not otherwise recommended by the doctor, the following doses may be applied:
Mucosal thrush-dose depends on the area of infection 50 mg once a day for 7-14 or 14-30 days. Doses are sometimes increased to 100 mg a.
Fungal skin infections 50 mg once a day for 2-4 weeks (up to 6 weeks for the athlete’s foot)
Systemic fungal infections 400 mg on the first day, then 200-400 mg once a day for 6-8 weeks or longer if necessary.
If you are AIDS patient, your doctor may use the drug indefinitely as 200 mg per day after full primary cycle to prevent recurrence.
50-400 mg once a day when you run the risk of getting an infection to prevent you from catching a fungal infection. If you are at high risk of systemic infection, it is 400 mg once a day.
Fluconazole administration is from the onset of patients with a decrease in the number of fragmented cells (neutropenia) in the previously predicted blood
it should start a few days ago and continue for another 7 days after the neutrophil count rises above 1000/mm3.
From Cryptococcus (a type of fungal infection)
Preventing an infection from coming back 100-200 mg once a day indefinitely
In patients with adequate immune system, 11-24 months in coccidioidomycosis in developing systemic fungal diseases, 2-17 months in paracoxidioidomycosis, 1-16 months in sporotricosis and 3-17 months in histoplasmosis, the appropriate time should be chosen for each patient.
Application path and method
It is taken from the mouth.
Fluconazole is given in the form of an intravenous infusion, both orally and at a rate not exceeding 10 ml per minute. The way of administration depends on the clinical condition of the patient. There is no need to change the daily dose when going intravenously or otherwise.
Different age groups
Use in children
4 weeks to 15 years old Mucosal infections 3 mg/kg once a day. 6 mg/ kg on the first day.
Systemic fungal infections 6-12 mg/kg once a day.
Preventing fungal infections 3-12 mg/kg once a day when there is a risk of getting an infection.
3-4 weeks The same dose as mentioned above, but given every 2 days. Maximum dose of 12 mg/kg every 2 days.
Less than 2 weeks The same dose as mentioned above, but given every 3 days. Maximum dose of 12 mg/kg every 3 days..
A maximum dosage of 400 mg per day should not be exceeded in children.
Use in the elderly
Normal adult dose will be given if you do not have kidney problems.
Special use cases
Kidney failure
No dose adjustment is required in treatment requiring a single dose. Your doctor may change your dose depending on your kidney infection.
Liver failure
Not available.
If you have an impression that the effect of LANDIMAX is too strong or weak, talk to your doctor or pharmacist.
If you used more LANDIMAX than you should use
Do not take more than the amount your doctor told you.
If you have used more than you should use LANDIMAX, talk to a doctor or pharmacist.
If you forget to use LANDIMAX
Do not take a double dose to balance the forgotten doses.
Effects that may occur when treatment with LANDIMAX is terminated
Do not stop taking LANDIMAX unless your doctor tells you. Your doctor will determine the best method for you when you need to stop taking LANDIMAX. If you have any questions about using LANDIMAX, consult your doctor.

DO NOT use LANDIMAX in the following cases
If,
If you have been hypersensitive to:
• To any component of LANDIMAX
• To other medicines you take to treat fungal infection.
Symptoms of hypersensitivity may include the difficulty of itching, skin redness or breathing.
• If you are taking terfenadine or astemizole, which is antihistamine to treat allergies
• If you are taking cisapride used for stomach disruption
• If you are sick with schizophrenia and are taking pimozide, an antipsychotic drug
• If you are taking quinidine-containing medication for heart rhythm disorder.
USE LANDIMAX CAREFUL in the following cases
If,
• If you have liver or kidney problems
• If the levels of potassium, calcium or magnesium in your blood are abnormal
• Especially if you have serious illnesses such as AIDS and cancer
• If you are potentially taking medication that damages or irritates multiple simultaneous liver and the underlying disease that will kill your liver tissues (hepatic necrosis) occurs. The condition of damaging or irritating your liver with fluconazole is reversible. Your doctor will follow you against severe liver damage during treatment, and you may discontinue your medication if necessary.
• If rash skin reactions develop, such as toxic epidermal necrolysis and Stevens-Johnson syndrome. If a disorder with a liquid-filled bubble feature or a hypersensitivity condition that usually passes spontaneously, creating redness similar to hand, face, and standing lace, your doctor may discontinue your treatment.
• If you use less than 400 mg of terfenadine per day
• The very severe response of the body to allergy-forming substances, if sudden hypersensitivity develops
• If you have electrolyte disorder
• If you are taking other medicines with fluconazole
• If you are taking concomitant medication that is not destroyed by CY3A4, an enzyme in the liver, but is known to prolong the QT interval in the ECG record
It has been observed that the QT interval is prolonged in the record (ECG) of the electrical activity of the heart with some azole group drugs, including fluconazole.
• If you have heart disease, including heart rhythm problems
• If there is a condition in the innate or documented heart that can lead to serious arrhythmias and sudden deaths
• You have acute, subacute or chronic disease in your heart adal, especially when there is heart failure
• If your heart beats less than 60 per minute (sinus bradycardia)
If these warnings apply to you, even at any time in the past, please consult your doctor.
Using LANDIMAX with food and drink
Not available.
Pregnancy
Consult your doctor or pharmacist before using the medicine..
Do not use LANDIMAX during pregnancy unless your doctor says the opposite.
If you notice that you are pregnant during your treatment, consult your doctor or pharmacist immediately.
Breastfeeding
Consult your doctor or pharmacist before using the medicine.
Do not use LANDIMAX during breastfeeding.
Driving and using machines
It should be noted that when driving or using machinery, occasional dizziness or seizures may occur.
Important information about some of the ingredients of LANDIMAX
If your doctor has previously been told that you have intolerance to some sugars, contact your doctor before taking this medicinal product.
This medicinal product contains less than 1 mmol (23 mg) sodium at each dose; no side effects are expected at this dose.
Use with other drugs
Since they should not be taken with LANDIMAX, tell your doctor immediately
• If you are taking terfenadine or astemizole, which is antihistamine to treat allergies
• If you are taking cisapride used for stomach disruption
• If you are sick with schizophrenia and are taking pimozide, an antipsychotic drug
• If you are taking quinidine-containing medication for heart rhythm disorder.
Concomitant use of erythromycin, an antibiotic with LANDIMAX, is not recommended.
If you are taking any of the following medicines, tell your doctor. Some drugs that may interact with LANDIMAX are as follows, with these medicinal products, their use requires precaution and dose adjustment
• Alfentanyl, fentanyl used in anesthesia
• Amitriptyline and nortriptyline used in the treatment of depression
Amphotericin B. used for severe fungal diseases
• Blood thinning warfarin (or similar drugs) to prevent blood clots
• Azithromycin, an antibiotic
• Benzodiazepines that help you sleep or like anxiety, anxiety, midazolam, triazolam
• Calcium channel blockers such as nifedipine, isradipine, amlodipine and felodipine, which are also blood pressure lowering and used in some heart diseases
• Selecoxib used in the treatment of joint liming
• Cyclophosphamide used in cancer treatment
• Halofantrin used in malaria treatment
• HMG-Co A reductase inhibitors used for lipid disorders, metabolized with CYP3A4 such as atorvastatin and simvastatin or CYP2C9 such as fluvastatin
• Losartan, a blood pressure lowering drug
• Methadone used in the treatment of heroin addiction
• Pain, fever and illihaba effective drugs such as Naproxen, lornoxicam, meloxicam, diclofenac
• Oral contraceptives, a birth control drug
• Endogenous steroids
• Prednisone used for acute organ rejection and antiinflammation
• Calmavir used in the treatment of AIDS disease
• Vinka alkaloids used in the treatment of various cancers
• Vitamin A
• Sugar disease drugs such as chlorpropamide, glibenclamide, glipizide or tolbutamide
• Water tablets such as hydrochlorothiazide used to treat liquid retention and high blood pressure
• Phenytoin, carbamazepine, used to control the palace
• Rifampicin or rifabutin, an antibiotic for infections
• Cyclosporin or tacrolimus to prevent transplant rejection
• Theophylline used to control asthma
• Zidovudine, also known as AZT, used in patients infected with the Human Immunodeficiency Virus (HIV)
If you are currently using any prescription or non-prescription medication or have used it recently, please inform your doctor or pharmacist about them.

Like all medicines, people who are sensitive to the ingredients of LANDIMAX may have side effects.
Although serious allergic reactions are rare, several people have an allergic reaction. If you experience any of the following symptoms, tell your doctor right away
• Sudden wheezing, difficulty breathing or chest tightness
• Eyelids, swelling on the face or lips
• Itching throughout the body, redness on the skin or itchy red spots
• Skin rash
• Severe skin reactions such as rash that cause swelling (may also affect the mouth and tongue)
• If you are AIDS patient, you are more likely to show severe skin reactions to drugs, including LANDIMAX.
Side effects are listed as shown in the categories below.
• Very common: It can be seen in at least 1 in 10 patients.
• Common: Less than one in 10 patients, but more than one in 100 patients.
Uncommon: Less than one in 100 patients, but more than one in 1,000 patients.
• Rare: Less than one in 1,000 patients.
• Very rare: Less than one in 10,000 patients.
• Unknown: Cannot be estimated from the available data.
Common
• Headache
• Abdominal pain
• Nausea
Vomiting
• Discomfort in the stomach
• Diarrhea
• Rash
• High alkaline phosphatase levels
• Increase in aspartate aminotransferase
• Increased blood alkaline phosphatase
Uncommon
• Insomnia
• Drowsiness
• Seizures
• Drowsiness
• Numbness
• Taste disorder
• Dizziness caused by balance disorder (vertigo)
Indigestion, digestive disorder
• Gas and dry mouth
• Slowdown or stopping of bile flow
• Jaundice
• Increase in the bilirubin
Itching
• Hives
• Increased sweating
• Muscle pain
• Fatigue
• Displeasure
• Don’t fall out of power
• Fire
Rare
• Decrease in the number of white blood cells
• Decrease in the number of fragmented cells in the blood
• Decrease in platelet-blood pulpit- count
• Very severe response of the body to allergy-forming substances, sudden hypersensitivity (including swelling in the face and throat as a result of allergies, percent edema, itching, hives)
• High cholesterol
• High triglyceride
• Blood potassium level rises above normal
• Shake
• QT prolongation
• Life-threatening irregular heart rhythm (torsade de pointes)
• Liver-related toxicity, which rarely results in death
• Liver failure
• Liver inflammation
• Death or damage to tissues that belong to liver cells or affect liver cells
• A serious disease (toxic epidermal necrolysis) that dilutes with liquid filled blisters inside the skin
• Inflammation (Stevens-Johnson syndrome) that dilutes with blood sitting, swelling and redness on the skin and around the eyes
Acute common exantematous pustulosis exfoliative skin diseases
• Percentage edema
• Hair loss
Pediatric patients
The incidence and model of adverse events recorded during pediatric clinical trials and laboratory abnormalities are comparable to those seen in adults.
If you encounter any side effects not mentioned in this use instruction, inform your doctor or pharmacist.

LANDIMAX should not be used in patients known to be sensitive to this drug, any of the inert components of the drug, or similar azole compounds..
According to the results of multiple dose interaction studies, terfenadine is contraindicated in patients receiving multiple doses of fluconazole in amounts of 400 mg or higher per day. Co-administration of other drugs such as cisapride, astemizole, pimozide and quinidine, which are known to prolong the QT interval and metabolized through the CYP3 A4 enzyme, is contraindicated in patients taking fluconazole (see. section 4.4 Special warnings and precautions for use and 4.5 Interactions with other medicinal products and other forms of interaction).

Pharmacotherapeutic group: Triazole derivatives
ATC code: J02AC
Fluconazole is a member of triazole-grade antifungal agents and is a potent and specific inhibitor of fungal sterol synthesis.
Fluconazole shows little pharmacological activity in a wide variety of animal studies. In mice, some prolongation in pentobarbital sleep time (p.o.) and anesthetized (IV) cats increased mean arterial and left ventricular blood pressure and heartbeat. High concentrations of inhibition were observed in the ovarian aromatase of the rat.
Fluconazole administered orally or intravenously is active in various fungal infection models in animals. Its activity has been demonstrated in opportunistic mycoses, including systemic candidiasis in immunocompromised animals; infections related to Cryptococcus neoformans, including intracranial infections; There are infections related to Microsporum and Trichophyton species. The activity of fluconazole has been shown in other endemic mycosis animal models; among them Blastomyces dermatitis; Coccidioides immitis, including intracranial infections; and Histoplasma capsulatum infections in both normal and immunosuppressive animals.
Other than Candida albicans, cases of superinfection have been reported with other Candida species (eg Candida krusei) that are generally not hereditary sensitive to fluconazole. These cases may require alternative antifungal therapy.
Fluconazole is very specific for enzymes dependent on fungal cytochrome P-450. Fluconazole, which is used up to 28 days as 50 mg per day, has been shown to not affect plasma testosterone concentrations in men or steroid concentrations in women of childbearing age. 200-400 mg fluconazole per day has no clinical significant effect in healthy male volunteers at endogenous steroid levels or in ACTH-stimulated response. Interaction studies with antipyrin have shown that 50 mg single or recurrent doses of fluconazole do not affect the metabolism of this substance.
Fluconazole efficacy in the head tinea has been studied in 2 randomized controlled trials consisting of a total of 878 patients comparing griseofulvin with fluconazole. Fluconazole at a dose of 6 mg/kg/day for 6 weeks is not superior to griseofulvine administered at a dose of 11 mg/kg/day for 6 weeks. In all treatment groups, 6. overall success rate per week is low (fluconazole at 6 weeks: 18.3%; fluconazole at 3 weeks: 14.7%; griseofulvin: 17.7%). These findings are not consistent with the natural story of the head tine without treatment.

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